Molecular dynamics simulation ( MD) is an effective method in peptide folding research. MD can be used to simulate the folding process of A β protein and the inhibition of aggregation at nanosecond time scale and molecular level. 分子动力学模拟(moleculardynamicssimulation,MD)为解决这一问题提供了有效的方法,应用MD方法可在纳秒水平研究Aβ蛋白质折叠过程,从分子水平分析聚集过程及抑制剂对聚集的抑制作用。